If you are using (which you should for TotK), Ryujinx will also store a separate pipeline cache. Do not delete the vulkan_pipeline.cache file.
For a long time, obtaining a TOTK shader cache was the first step in any PC player’s journey. However, as Ryujinx developers optimized the code and introduced "Profiled Persistent Buffer Cache" updates, the need for manually swapping cache files diminished. The emulator became smarter, handling the translation more efficiently and storing its own data better. ryujinx totk shader cache