Good news: Many users report that AutoCAD 2010 portable runs on Windows 11 64-bit, despite being 14 years old. However, you need these tweaks:

It typically does not modify system registry files, making it easier to use on multiple workstations.

Users can carry their entire CAD environment, including custom settings and palettes, on a thumb drive to use across different workstations. Critical Risks and Downsides